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RFA-FD-25-020
Simpler.Grants.gov

Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)

Food and Drug Administration (HHS-FDA)

Up to $900,000
Due May 16, 2028
At a glance
Complex

This grant is designed to support clinical trials that test the safety and effectiveness of new treatments for rare diseases. The goal is to help develop more approved treatments for these diseases by funding innovative and collaborative trials.

Who it's for: This grant is for organizations that conduct clinical trials, specifically those focused on developing new treatments for rare diseases. This could include research institutions, hospitals, or other entities involved in medical research.

More details

Likely Disqualifiers

  • Proposals not focused on rare diseases
  • Lack of a clinical trial component
  • Applications not demonstrating unmet needs
  • Projects outside the scope of new indications or labeling changes
  • Incomplete applications

What You May Need

  • Detailed project proposal
  • Clinical trial design
  • Budget justification
  • Proof of unmet needs in rare diseases
  • Organizational capability statement
  • Letters of support or collaboration
  • Regulatory compliance documentation
  • Previous research findings
  • Institutional Review Board (IRB) approval
  • FDA regulatory pathway plan

Cautions

  • Ensure the focus is on rare diseases
  • Must include a clinical trial component
  • Application must clearly demonstrate unmet needs
  • Compliance with FDA regulations is critical
  • Projects must aim for new indications or labeling changes

Generated from official source details for readability

Eligibility

Eligible Applicant Types

Other

Additional Criteria

Eligible applicants are those classified under 'OTHER' types, which typically include research institutions, hospitals, or other entities involved in conducting clinical trials. The specific focus must be on rare diseases, with projects aiming to address unmet needs through new indications or changes in labeling.

Overview

This grant is for organizations that conduct clinical trials, specifically those focused on developing new treatments for rare diseases. This could include research institutions, hospitals, or other entities involved in medical research.

Likely Disqualifiers

  • Proposals not focused on rare diseases
  • Lack of a clinical trial component
  • Applications not demonstrating unmet needs
  • Projects outside the scope of new indications or labeling changes
  • Incomplete applications

Use of Funds

Funds can be used to conduct clinical trials that test the safety and efficacy of treatments for rare diseases. This includes costs related to trial design, implementation, and analysis.

Cost Sharing

Not Required

Important Dates

Posted
Jul 11, 2025
Deadline
May 16, 2028(703 days)
Archive Date
Jun 15, 2028
Last Updated
May 13, 2026

Application Checklist

0/6 complete
  • Register your organization with necessary federal systems
  • Prepare a detailed clinical trial proposal
  • Develop a comprehensive budget plan
  • Gather supporting documents and letters
  • Ensure compliance with FDA and IRB requirements
  • Submit application by the deadline

Award Range

$0 - $900,000

Deadline

May 16, 2028

Official Source

Always review the official grant listing for the most accurate and up-to-date information.

View Official Listing

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